Preheat the oven to 350 degrees. Bring a pot of water to a boil and add the penne. Cook according to package directions. Drain and rinse it and set it aside.
In a medium saucepan over medium-high heat, add butter, heavy whipping cream, and cream cheese. Cook until melted. Add the minced garlic, garlic powder, Italian seasoning, and salt and pepper. Continue to whisk until smooth. Add the grated parmesan cheese. Bring to a simmer and continue to cook for about 3-5 minutes or until it starts to thicken.
Add the pasta back to the pot and pour the Alfredo Sauce over it. Then add in the chicken, and stir everything together.
Add half of the pasta mixture to a 9x13 baking dish and top with 1 cup mozzarella. Then, add the rest of the pasta mixture to the dish and top with the remaining mozzarella and parmesan cheese. Bake for 20-30 minutes until the cheese is golden and bubbly.