Preheat the oven to 350 degrees Fahrenheit and spray a 9x13-inch baking dish with non-stick cooking spray.
Cook the 12 ounces cellentani pasta until al dente in generously salted water (don't overcook). Drain and set aside.
Meanwhile, cook the 1 pound lean ground beef and 1 chopped small onion in a large skillet over medium-high heat until no longer pink. Add the 5 minced garlic cloves and saute for 30 seconds. Drain off any excess grease.
Turn the heat to low and stir in 1 (14.75-ounce) can sweet creamed corn, 1 cup tomato sauce, 1 (10-ounce) can mild enchilada sauce, 1 (14.5-ounce) can petite diced tomatoes, 1 (15-ounce) can red kidney beans, 1 (4-ounce) can mild diced green chilies, 1 teaspoon chili powder, 1 teaspoon cumin, ½ teaspoon smoked paprika, 1 teaspoon salt, and ¼ teaspoon pepper. Simmer uncovered for 10 minutes.
Stir in the 4 ounces cubed cream cheese until melted, then stir in half of the 1 ½ cups shredded cheddar cheese, and half of the 1 ½ cups Pepper Jack cheese, cheese until melted. Add pasta and stir until evenly coated.
Pour the mixture into the prepared pan, sprinkle with the remaining cheeses, and bake for 25 minutes, broil for the last few minutes to brown the cheese.
Remove the dish from the oven and garnish with tortilla strips, tomatoes, avocados, sour cream, cilantro, and hot sauce, if desired.