Preheat oven to 400 degrees Fahrenheit and lightly spray a baking sheet with non-stick cooking spray.
Cut the 1 (16-ounce) tube refrigerated biscuits in half so there are 16 biscuits, then flatten each piece. Place 2 pepperoni slices and one piece of the 3 mozzarella cheese sticks cut into 6 pieces, in the center of a biscuit.
Fold and pinch the edges together to seal the pepperoni and cheese inside. Repeat with remaining biscuits, pepperoni slices, and cheese.
Place 2 tablespoons olive oil in a small bowl. In another bowl stir together ½ teaspoon garlic powder, 3 teaspoons Italian seasoning, and ½ cup grated parmesan cheese.
Dip the top half of each biscuit into the olive oil, then roll in the parmesan mixture.
Place the biscuits on the prepared baking sheet and bake for 12-15 minutes until golden. Serve warm.