Preheat the oven to 400 degrees Fahrenheit. Open 1 (12-ounce) tube refrigerated buttermilk biscuits.
Roll each biscuit into a 12-inch rope and tie into a knot; tuck ends under.Place 2 inches apart on a greased baking sheet.
Bake for 8-10 minutes or until golden brown.
In a medium bowl, combine ¼ cup melted unsalted butter,3 tablespoons grated Parmesan cheese, ½ teaspoon garlic powder, 1 teaspoon dried oregano, and 1 teaspoon dried parsley flakes. Stir the ingredients together and brush the warm knots with the butter mixture.