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My favorite homemade garlic alfredo sauce is combined with pesto giving this casserole amazing flavor! It is creamy and delicious and sure to be a hit at the dinner table!
pesto alfredo chicken casserole in a white baking dish with a wooden spoon.

Isn’t it funny the things that excite us when we become adults? I finally got a nice chest freezer to store all of my frozen foods and Costco finds. I was so excited to get it and put it in my basement it felt like Christmas. My boys are getting to an age where they are always hungry and eating, and our freezer upstairs just wasn’t going to cut it anymore.

I love to make a big casserole and freeze the other half for later. Now I have my own little section in my chest freezer with all of my frozen meals. Does anyone else get excited over little things like this? Maybe I am the only one out there to get so excited about a chest freezer. 🙂

pesto alfredo chicken casserole in a white bowl.

This casserole made a big 9×13 batch and I was able to divide it into two and freeze the other half for later. And to tell you the honest truth, I think this is one of the best casseroles that I have ever had.

Not only is it made with my famous and amazing alfredo sauce, it has the added flavor of pesto. Two of my favorite things combined to make this casserole creamy, flavorful, and delicious. It also had spinach and crushed tomatoes hidden throughout. This casserole is simple but so delicious!

pesto alfredo chicken casserole in a white serving bowl.

Oh and don’t forget the ooey gooey cheese inside with each and every bite. This casserole just keeps getting better. I loved how it is topped with bread crumbs adding a crunchy texture to the top. It is seriously awesome!

This became an instant family favorite and I know that it will be a hit at the dinner table!

pesto chicken alfredo casserole in a white serving dish.

Recipe adapted from Taste of Home


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Pesto Alfredo Chicken Casserole

5 from 2 votes
By: Alyssa Rivers
My favorite homemade garlic alfredo sauce is combined with pesto giving this casserole amazing flavor!  It is creamy and delicious and sure to be a hit at the dinner table!
Prep Time: 20 minutes
Cook Time: 30 minutes
Total Time: 50 minutes
Servings: 8 Serving


Alfredo Sauce:



  • Preheat oven to 350 degrees. Lightly spray a 9x13 inch pan with cooking spray and set aside. Cook the pasta in a large pot according to package directions. In a large bowl combine cooked chicken, 1 cup cheese, spinach, and tomatoes.
  • To make the alfredo sauce: In a medium saucepan add butter, heavy whipping cream, and cream cheese. Cook over medium heat and whisk until melted. Add the jar of pesto. Add the minced garlic, garlic powder, italian seasoning, salt and pepper. Continue to whisk until smooth. Add the grated parmesan cheese. Bring to a simmer and continue to cook for about 3-5 minutes or until it starts to thicken.
  • Drain the pasta and add alfredo sauce to the large bowl and toss with ingredients to coat. Pour into the prepared 9x13 inch pan. Add remaining cheese to the top of the casserole. In a small bowl, combine the bread crumbs, Parmesan cheese and oil. Sprinkle over casserole.
  • Cover with foil and bake for 30-40 minutes or until cooked throughout and bubbling on the sides.


* If you are freezing, Cover and freeze one casserole for up to 3 months. Take out the night before to thaw before baking.


Calories: 877kcalCarbohydrates: 55gProtein: 27gFat: 62gSaturated Fat: 30gCholesterol: 155mgSodium: 884mgPotassium: 453mgFiber: 4gSugar: 5gVitamin A: 3156IUVitamin C: 8mgCalcium: 384mgIron: 2mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Additional Info

Course: Dinner, Main Course
Cuisine: Italian American
Tried this recipe?Mention @alyssa_therecipecritic or tag #therecipecritic!

About Alyssa Rivers

Alyssa Rivers is the author of 'The Tried and True Cookbook', a professional food photographer and experienced recipe-developer. Having a passion for cooking, her tried and true recipes have been featured on Good Morning America, Today Food, Buzzfeed and more.

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Recipe Rating


  1. 5 stars
    This is FIRE. Def gonna be a staple in my house. I make a lot of recipes and this one the first one that really surprised me on how good it is.

  2. 5 stars
    This is a very tasty decadent recipe. Alyssa Rivers very good instructions and there are some helpful comments.
    I don’t think I ever before used shredded, Italian cheese. It adds a wonderful flavor that really made this dish taste great. I will be using it for other meals in the future.
    I had some very ripe tomatoes that needed to be used up.
    I used Newman’s Own Alfredo Sauce and vegetable penne.

  3. Can this be assembled the night before and baked the next day? Or…. If I make the Alfredo sauce ahead of time do I need to slowly heat before assembly and bake or is the casserole oven bake slow enough that it won’t separate?

  4. This is absolutely delicious. My only suggestion would be to def use diced tomatoes instead of crushed. The crushed tomatoes turned my beautiful pesto Alfredo sauce pink, even after draining them. The taste is still amazing but for presentation go with diced.

  5. This was fantastic! I subbed rotini for the penne and diced tomatoes instead of crushed tomatoes.

  6. This was such a great recipe. I’m glad I tried it! I did add 3 cups of heavy cream instead of 2 cups and my jar of pesto was 6.5 ounces instead of 8. It was delicious.

  7. I love freezing foods for future use. this recipe looks worthy of trying. I always purchase fresh vegetables, onions, peppers, tomatoes, celery, chop and blanche them and freeze to take out for recipes, soups, casseroles;
    even better when buying fir a great sale price to freeze

  8. Haha, I would totally get excited about a new freezer! We have 3 if you include the one on the fridge. And I love filling them up with meals for later! This one is definitely going on the list 🙂